Phenothiazines in prill form

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 279/20 (2006.01)

Patent

CA 2393258

The invention relates to (a) phenothiazine or a phenothiazine analog or derivative (phenothiazine material) in the form of prills of a generally spherical shape containing very low levels of fines and also (b) a method of forming a phenothiazine material in prill form having a generally spherical shape. The prilled phenothiazine material exhibits improved handling, flowability and dissolation times, while minimizing the generation of fines, and the problems of irritation and sensitization through exposure to such fines.

L'invention concerne (a) une phénothiazine ou un analogue ou un dérivé de phénothiazine (matière de phénothiazine) en forme de granules généralement sphériques contenant de très faibles niveaux de fines et (b) également un procédé de formation d'une matière de phénothiazine en forme de granules généralement sphériques. La matière de phénothiazine en forme de granule présente une comportement, une aptitude à l'écoulement et des temps de dissolution améliorés, tandis que sont minimisés la génération de fines et les problèmes d'irritation et de sensibilisation lors d'expositions à de telles fines.

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