Isolated peptides which bind to hla-c molecules and uses...

Details Isolated peptides which bind to hla-c molecules and uses... Isolated peptides which bind to hla-c molecules and uses...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 5/0783 (2010.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2423481

The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.

L'invention concerne des épitopes peptidiques qui se lient aux molécules HLA-Cw3 et HLA-Cw6 sur la surface des cellules. Ces peptides sont utiles en diagnostic et en thérapeutique, de même que le sont les molécules d'ADN qui les codent, ainsi que les lymphocytes T cytolytiques, spécifiques des complexes HLA/peptides. L'invention concerne également un procédé d'identification de molécules pertinentes, telles que celles décrites dans l'invention, dans un système mettant en oeuvre la stimulation et la restimulation à l'aide de différents vecteurs viraux.

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