Methods for treatment of beta-amyloid protein-induced ocular...

A - Human Necessities – 61 – K

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A61K 36/9068 (2006.01) A61K 31/121 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/365 (2006.01) A61K 36/16 (2006.01) A61K 36/53 (2006.01) A61K 36/537 (2006.01) A61K 36/9066 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2611490

The invention provides methods for treating beta-amyloid protein-involved ocular disease including age-related macular degeneration and glaucoma, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., and Rosmarinus sp. and synthetic chemical analogues thereof, for the treatment of a beta-amyloid protein-involved ocular disease.

La présente invention concerne des procédés pour le traitement de maladies oculaires induites par les protéines bêta-amyloïdiennes, et notamment le glaucome et la dégénérescence maculaire liée à l'âge, des composés et compositions pharmaceutiques à cet effet, et l'utilisation de ces composés pour la fabrication d'un médicament à cet effet. L'invention concerne plus particulièrement l'utilisation de composés de produits naturels tirés des espèces Curcuma, Zingiber, Ginkgo biloba, Salvia, et Rosmarinus, et de certains de leurs analogues synthétiques, pour le traitement de maladies oculaires induites par les protéines bêta-amyloïdiennes.

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