C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/58 (2006.01) A61K 31/4164 (2006.01) A61K 31/4427 (2006.01) A61P 29/00 (2006.01) C07D 233/64 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2711464
A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula (1) wherein n=1-4; X is C or N; R1-R6 can be the same or different and are independently selected from the group consisting of H, C1-6 alkyl, OCH3, OH, F, Cl, Br, CH2OH, CH2N(R )2, C(O)R , CH2CN, CF3; wherein R is H or C1-6 alkyl; and R8 is C1-6 alkyl or aryl. The compounds of Formula (1) can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.
L'invention porte sur un composé, présentant une activité modulatrice sélective sur les récepteurs adrénergiques alpha 2b et/ou alpha 2c, et de formule générale (I) dans laquelle: N = 1-4; X est C ou N; R1-R6 qui peuvent identiques ou différents sont sélectionnés indépendamment parmi H, C1-6 alkyle, OCH3, OH, F, Cl, Br, CH2OH, CH2N(R7)2, C(O)R8, CH2CN, CF3; et dans laquelle: R7 est H ou C1-6 alkyle; et R8 est C1-6 alkyle ou aryle. Les composés de formule (I) peuvent s'incorporer à des préparations pharmaceutiques et s'utiliser dans des méthodes de traitement de maladies et états médiés par le récepteur alpha 2.
Bhat Smita S.
Chow Ken
Garst Michael E.
Heidelbaugh Todd M.
Sinha Santosh C.
Allergan Inc.
Gowling Lafleur Henderson Llp
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