Fragmented polymeric hydrogels for adhesion prevention and...

Details Fragmented polymeric hydrogels for adhesion prevention and... Fragmented polymeric hydrogels for adhesion prevention and...

C - Chemistry, Metallurgy

08

L

C08L 101/14 (2006.01) A61K 9/00 (2006.01) A61K 31/785 (2006.01) A61K 47/42 (2006.01) A61L 27/52 (2006.01) A61P 17/02 (2006.01) A61P 41/00 (2006.01) C08J 3/075 (2006.01) C08L 5/00 (2006.01) C08L 89/00 (2006.01) C08L 101/16 (2006.01) A61B 19/02 (2006.01) A61M 5/178 (2006.01)

Patent

CA 2264647

Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice at the target site. Alternatively, the gels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.

Des gels moléculaires réticulés comprennent une variété de polymères biologiques et non-biologiques, tels que des protéines, des polysaccharides et des polymères synthétiques. Ces gels moléculaires peuvent être appliqués sur des sites cibles dans le corps d'un patient, par extrusion du gel à travers un orifice au niveau du site cible. Dans un autre mode de réalisation, les gels peuvent être rompus mécaniquement et utilisés dans des articles implantables tels que des prothèses mammaires. Lorsqu'on les utilise in vivo, les compositions sont utiles pour inhiber les adhésions spinales et tissulaires post-chirurgicales, afin de remplir des évidements tissulaires, des voies tissulaires, des cavités corporelles, des imperfections chirurgicales et analogues.

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