Hydroxyphenyl derivatives with hiv integrase inhibitory...

C - Chemistry – Metallurgy – 07 – C

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C07C 237/22 (2006.01) A61K 31/16 (2006.01) A61K 31/166 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/401 (2006.01) A61K 31/405 (2006.01) A61K 31/4172 (2006.01) A61K 38/05 (2006.01) A61P 31/18 (2006.01) C07C 235/34 (2006.01) C07C 235/52 (2006.01) C07C 279/14 (2006.01) C07C 323/59 (2006.01) C07C 323/60 (2006.01) C07D 207/16 (2006.01) C07D 209/20 (2006.01) C07D 233/64 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2302144

An hydroxyphenyl derivative selected from the group consisting of a compound of formula (see above formula) and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts thereof and when a compound of formula I comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein n is 1, 2 or 3, a is 1, 2 or 3, Hal represents a halogen atom (e.g. Cl, Br, F or I), p is 0, 1 or 2, r is 0, 1 or 2, X and X' each independently represents a single bond, a saturated straight or branched hydrocarbon group of 1 to 4 carbon atoms or a straight or branched hydrocarbon group of 2 to 4 carbon atoms comprising a carbon to carbon double bond, R a represents H or -CH3, and R aa represents H or -CH3; W may represent an amino acid residue or fragment. These compounds may be used to inhibit the activity of HIV integrase.

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