Anti-adhesive composition, solid preparation, and process...

Details Anti-adhesive composition, solid preparation, and process... Anti-adhesive composition, solid preparation, and process...

A - Human Necessities

61

K

A61K 47/38 (2006.01) A61K 9/24 (2006.01) A61K 9/70 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2755687

An adhesion of a preparation 1 to an inner wall of an oral cavity is prevented by applying an anti-adhesive composition containing a water-soluble cellulose ether (e.g., an HPMC) and an anionic polymer (e.g., a carboxyvinyl polymer) to a gel-forming layer 4 covering a drug-containing unit 2 to form an anti-adhesive layer 5. The gel-forming layer 4maybe formed with a gel-forming agent (a carboxyvinyl polymer), a crosslinking agent, and a base material (e.g., a poly(vinyl alcohol)). An adhesive layer 3 may be interposed between the drug-containing unit 2 and the gel-forming layer 4.

La présente invention concerne une couche formant un gel (4), recouvrant une partie contenant un médicament (2) qui est recouverte d'une couche empêchant l'adhésion (5). Pour ce faire, on applique à la couche formant un gel (4) une composition empêchant l'adhésion, qui contient un éther de cellulose soluble dans l'eau (tel que HPMC) et un polymère anionique (tel que le polymère carboxyvinyle), de telle sorte que la préparation (1) n'adhère pas à la paroi interne de la cavité orale. La couche formant un gel (4) peut être formée à partir d'un agent formant un gel (un polymère carboxyvinyle), un agent de réticulation, et un agent de base (un alcool polyvinylique ou analogue). En outre, une couche adhésive (3) peut être intercalée entre la partie contenant le médicament (2) et la couche formant le gel (4).

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