C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2517767
The present invention provides a composition comprising an isolated F-spondin polypeptide specifically bound to an APP or APLP polypeptide. The present invention further provides a composition comprising an isolated neurexin polypeptide specifically bound to an APP or APLP polypeptide. Also provided are methods of screening for modulators of the binding of an APP or an APLP polypeptide by F-spondin or neurexin proteins. Modulators of the binding of an APP or an APLP polypeptide by F-spondin or neurexin proteins may be useful in the treatment or prevention of AD.
L'invention concerne une composition renfermant un polypeptide de la F-spondine isolé lié de manière spécifique à un polypeptide APP ou APLP. L'invention concerne également une composition renfermant un polypeptide de la neurexine isolé lié de manière spécifique à un polypeptide APP ou APLP, ainsi que des procédés de balayage de modulateurs de la liaison d'un polypeptide APP ou APLP par des protéines de la F-spondine ou de la neurexine. Les modulateurs de la liaison d'un polypeptide APP ou APLP par des protéines de la F-spondine ou de la neurexine peuvent être utiles dans le traitement ou la prévention de AD.
Ho Angela
Sudhof Thomas C.
Board Of Regents The University Of Texas System
Shapiro Cohen
LandOfFree
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