Nitric ester derivatives

Details Nitric ester derivatives Nitric ester derivatives

C - Chemistry, Metallurgy

07

C

C07C 219/14 (2006.01) A61K 31/21 (2006.01) A61K 31/222 (2006.01) C07C 233/25 (2006.01)

Patent

CA 2381409

Compounds or their salts of general formula (I): A-B-N(O)s wherein: s is an integer equal to 1 or 2; A = R-T1-, wherein R is the drug radical and T1 = (CO)t or (X)t', wherein X = O, S, NR1c, R1c is H or a linear or branched alkyl or a free valence, t and t' are integers and equal to zero or 1, with the proviso that t = 1 when t' = 0; t = 0 when t' = 1; B = -TB -X2-O- wherein TB = (CO) when t = 0, TB = X when t' = 0, X being as above defined; X2, bivalent radical, is such that the precursor drug of A and the precursor of B meet respectively the pharmacological tests described in the description.

Cette invention concerne des composés ou leur sels représentés par la formule générale (I): A-B-N(O)s. Dans cette formule, s est un entier égal à 1 ou 2; A = R-T1- où R est le radical du médicament et T1 = (CO)t ou (X)t' , où X = O, S, NR1c ; R1c étant H ou un alkyle linéaire ou ramifié ou une valence libre ; t et t' sont des entiers égaux à = 0 ou 1, à condition que t = 1 lorsque t' = 0; t = 0 lorsque t' = 1; B = -TB-X2-O- où TB = (CO) lorsque t = 0, TB = X lorsque t' = 0, X étant défini comme ci-dessus; X2, radical bivalent, est tel que le médicament précurseur de A et le précurseur de B satisfassent aux essais pharmacologiques du descriptif.

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