C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 16/12 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2422204
The invention described herein provides for human antibodies produced in non- human animals that specifically bind to Pseudomonas aeruginosa Lipopolysaccharide (LPS). The invention further provides methods for making the antibodies in a non-human animal, expression of the antibodies in cell lines including hybridomas and recombinant host cell systems. Also provided are kits and pharmaceutical compositions comprising the antibodies and methods of treating or preventing pseudomonas infection by administering to patient the pharmaceutical compositions described herein.
La présente invention concerne des anticorps humains produits dans des animaux non humains et qui se lient spécifiquement au lipopolysaccharide (LPS) de Pseudomonas aeruginosa. L'invention concerne également des procédés de confection de ces anticorps dans un animal non humain, l'expression de ces anticorps dans les lignées cellulaires comprenant des hybridomes et des systèmes de cellules hôtes recombinantes. L'invention concerne enfin, d'une part des nécessaires et des compositions pharmaceutiques comprenant ces anticorps, et d'autre part des procédés s'appliquant au traitement ou à la prévention de l'infection par les pseudomonas, par administration au patient des compositions pharmaceutiques de l'invention.
Kamboj Kulwant Kauer
Schreiber John R.
Kamboj Kulwant Kauer
Schreiber John R.
Smart & Biggar
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