Novel imidazolidine derivatives, their preparation, their...

Details Novel imidazolidine derivatives, their preparation, their... Novel imidazolidine derivatives, their preparation, their...

C - Chemistry, Metallurgy

07

K

C07K 5/072 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) C07D 233/74 (2006.01) C07D 233/86 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01) C07F 9/6506 (2006.01) C07F 9/6558 (2006.01) C07K 5/02 (2006.01) C07K 5/087 (2006.01) C07K 5/097 (2006.01) C07K 5/10 (2006.01) C07K 5/107 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247551

The present invention relates to novel imidazolidine derivatives of theformula I, Image in which B, E, W, Z, R, R0, R2, R3, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of illnesses which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use in the therapy and prophylaxis of the disease states mentioned and pharmaceutical preparations which contain compounds of the formula I.

La présente invention porte sur de nouveaux dérivés d'imidazolidine de formule I Image , où B, E, W, Z, R, R0, R2, R3, e et h ont la signification donnée dans les revendications. Les composés de formule I sont des composés pharmaceutiques très utiles, notamment pour le traitement et la prévention de troubles inflammatoires comme la polyarthrite rhumatoïde ou les allergies. Les composés de formule I sont des inhibiteurs de l'adhésion et de la migration des leucocytes et (ou) des antagonistes du récepteur d'adhésion VLA-4, appartenant au groupe des intégrines. Ils conviennent généralement pour le traitement ou la prévention d'affections causées par une extension indésirable de l'adhésion leucocytaire et (ou) de la migration leucocytaire, ou qui y sont associées, ou dans lesquelles les interactions cellule-cellule ou cellule-matrice, qui sont basées sur les interactions des récepteurs VLA-4 avec leurs ligands, jouent un certain rôle. L'invention porte aussi sur des méthodes pour la préparation des composés de formule I, sur leur emploi pour le traitement et la prévention des états maladifs susmentionnés, et sur des préparations pharmaceutiques renfermant les composés de formule I.

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