Clostridial neurotoxins for use in tissue healing

A - Human Necessities – 61 – K

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A61K 39/08 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2580122

Naturally occurring and/or modified Clostridium neurotoxins, including those neurotoxins free of complexing proteins which naturally form complexes with Clostridial neurotoxins, are used to enhance healing of injured surface or superficial tissue of a patient by local administration into or in close proximity to the injured tissue. Such neurotoxins may be advantageously employed in wound healing and preventing scar formation, and find applicability in the area of ophthalmology, e.g. in treatment of injured corneal tissue, for example by closing inflamed eyes. A further embodiment includes diagnostic usage for the evaluation of effective toxin administration and medicaments for use therein.

L'invention porte sur des neurotoxines naturelles et/ou modifiées de <i>Clostridium </i>neurotoxins, y compris les neurotoxines exemptes de protéines complexantes formant naturellement des complexes avec les neurotoxines clostridiennes, et qui sont utilisées pour favoriser la cicatrisation de surfaces ou de tissus superficiels de patients par administration locale sur ou à proximité du tissu lésé. Ces neurotoxines, qui peuvent être avantageusement utilisées pour la guérison des plaies et la prévention des cicatrices, ont des applications dans les domaines de l'ophtalmologie, par exemple dans le traitement de lésions des tissus cornéens, notamment pour la fermeture des yeux enflammés. Elles peuvent également servir à des fins de diagnostic, pour évaluer l'administration de toxines et les médicaments en guérissant.

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