C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/088 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61P 25/00 (2006.01) C07D 307/79 (2006.01) C07D 317/54 (2006.01) C07D 319/18 (2006.01)
Patent
CA 2606269
The present patent application concerns new compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a saturated nitrogen-containing ring, A is a saturated C1 -4 alkylene and B a C3-4 alkylene or alkenylene chain; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.
La présente invention concerne de nouveaux composés représentés par la formule (I) dans laquelle R1 et R2 conjointement à l'atome d'azote auquel ils sont rattachés forment un noyau saturé contenant de l'azote, A est un alcoylène C1-4 saturé et B une chaîne alcoylène ou alcénylène C3-4. L'invention concerne également leur préparation et leur utilisation comme ligands du récepteur H3 dans le traitement, par exemple, des troubles du SNC tels que la maladie d'Alzheimer.
Bertrand Isabelle
Capet Marc
Lecomte Jeanne-Marie
Levoin Nicolas
Ligneau Xavier
Bioprojet
Robic
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