Antibodies to human il-1.beta.

Details Antibodies to human il-1.beta. Antibodies to human il-1.beta.

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2420231

An IL-1.beta. binding molecule, in particular an antibody to human IL-1.beta., especially a human antibody to human IL-1.beta.is provided, wherein the CDRs of the heavy and light chains having amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.

L'invention concerne une molécule de liaison appelée IL-1.beta., en particulier un anticorps de la IL-1.beta. humaine; spécifiquement un anticorps humain de la IL-1.beta. humaine, dans laquelle les régions hypervariables des chaînes lourdes et légères possédant des séquences aminoacides comme définies, sont utilisées dans le traitement d'une affection ou d'un trouble induit par la IL-1, par exemple, l'ostéoarthrite, l'ostéoporose et d'autres arthrites inflammatoires.

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