Piperidine derivatives and agent comprising the derivative...

Details Piperidine derivatives and agent comprising the derivative... Piperidine derivatives and agent comprising the derivative...

C - Chemistry, Metallurgy

07

D

C07D 211/64 (2006.01) A61K 31/451 (2006.01) C07D 211/22 (2006.01)

Patent

CA 2418313

Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): (see formula I) Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is useful for preventing and/or treating inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, osteoporosis, bone fracture, obesity, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia and the like.

La présente invention concerne des dérivés de pipéridine représentés par la formule générale (I) ou certains de leurs sels non toxiques, les différents symboles de la formule étant tels que définis dans la description. Leur activité inhibitrice des PDE4 fait que les composés représentés par la formule générale (I) conviennent pour la prévention et/ou le traitement d'affections de nature inflammatoire, diabétique, allergique, auto-immune, ainsi que de l'ostéoporose, des fractures osseuses, de l'obésité, de la dépression, de la maladie de Parkinson, de l'accident de reperfusion à épisode ischémique, et la leucémie, notamment.

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