C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2041031
31,251 IMPROVED PROCESS FOR THE SYNTHESIS OF N-[3-1H-IMIDAZOL-1-YL)PHENYL-4- (SUBSTITUTED)-2-PYRIMIDINAMINES ABSTRACT The invention provides a novel process for producing N-[3-(1H-imidazol-1-yl-4-(substituted-2- pyrimidinamine compounds in which the substituent is a 2-pyridinyl, 3-pyrindinyl, 4-pyridinyl, 2-furanyl or 2-thienyl group. The process includes the steps of (1) reacting a 3-(1H-imidazol-1-yl)benzamine with cyanamide and a halogen acid while controlling the pH of the reaction between pH about 2 to about 3.5 and recovering a [3-(1H-imidazol-1-yl)phenyl] guanidine dihydrohalide and (2) reacting the [3-(1H-imidazol-1-yl)phenyl] quanidine dihydrohalide so recovered with an appropriately substituted 3-dimethylamino-1-(substitut- ed)-2-propen-1-one and a base at a pH of from about 10.5 to about 11.5 and recovering the N-[3-(1H-imidaz- ol-1-yl)phenyl-4-(substituted)-2-pyrimidamine compound so produced. The novel process provides improved yield and purity by adhering to the stated crucial pH ranges.
American Cyanamid Company
Smart & Biggar
LandOfFree
Process for the synthesis of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the synthesis of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1452194