Novel p2x7r antagonists and their use

Details Novel p2x7r antagonists and their use Novel p2x7r antagonists and their use

C - Chemistry, Metallurgy

07

D

C07D 209/30 (2006.01) A61K 31/404 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2758474

The present application is directed to novel P2X7R antagonists that are N- indol-3-yl- acetamide and N-azaindol-3- yl-acetamide compounds, pharmaceutical compositions comprising the same and their use for the prophylactic or therapeutic treatment of diseases mediated by P2X7R activity.

La présente invention porte sur de nouveaux antagonistes de P2X7R qui sont des composés N-indol-3-yl-acétamide et N-azaindol-3-yl-acétamide, sur des compositions pharmaceutiques les renfermant et sur leur utilisation pour le traitement prophylactique ou thérapeutique de maladies à médiation par l'activité de P2X7R.

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