Optical immunoassay

Details Optical immunoassay Optical immunoassay

G - Physics

01

N

G01N 21/77 (2006.01) G01N 21/45 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G02B 6/122 (2006.01) G01J 9/02 (2006.01) G02B 6/12 (2006.01)

Patent

CA 2072998

In apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a reference path to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. A ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a serpentine path.

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