Immunological reagent specifically interacting with the...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2335090

The present invention relates to a nucleic acid molecule comprising a nucleic acid sequence encoding at least one complementary determining region (CDR) of a variable region of an antibody, said antibody specifically interacting with the extracellular domain of the human zeta-chain, said antibody being obtainable by immunizing a rat with Jurkat cells and subsequently with a conjugate comprising a carrier molecule and a peptide comprising the 11N- terminal amino acids of the rat zeta-chain. Preferably, the (poly)peptide encoded by the nucleic acid molecule of the invention is a monospecific or bispecific antibody. The invention also relates to pharmaceutical compositions comprising i.a. the nucleic acid molecule or antibody of the invention as well as to kits comprising the aforementioned compounds. Finally, the invention relates to a method for the determination of zeta-chain or eta-chain expression on NK-cells, T-cells or precursors thereof employing the antibody of the invention.

L'invention concerne une molécule d'acide nucléique contenant une séquence d'acide nucléique codant pour au moins une région hypervariable (CDR) d'une région variable d'un anticorps. Ce dernier interagit spécifiquement avec le domaine extracellulaire de la chaîne zêta humaine et peut être obtenu en immunisant un rat avec des cellules de Jurkat et ultérieurement avec un conjugué comprenant une molécule porteuse et un peptide comprenant les 11 acides aminés N-terminaux de la chaîne zêta du rat. De préférence, le (poly)peptide codé par la molécule d'acide nucléique selon l'invention est un anticorps monospécifique ou bispécifique. L'invention concerne également des compositions pharmaceutiques comprenant, entre autres, la molécule d'acide nucléique ou anticorps selon l'invention ainsi que des trousses comprenant les composés susmentionnés. L'invention concerne enfin une méthode permettant de déterminer l'expression de chaîne zêta ou êta sur les cellules NK ou les lymphocytes T ou leurs précurseurs, au moyen de l'anticorps selon l'invention.

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