Pyridazinone derivatives

Details Pyridazinone derivatives Pyridazinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 237/22 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2053863

Disclosed are a novel compound of the formula: Image (wherein R1 is H, alkyl, alkenyl, or carboxy- or alkoxycarbonyl-alkyl, R2 is A1-Y1 or A2 y2 R3 and R4 are H or alkyl, X is Cl, Br, H or CN, Ar is aromatic group, A1 and A2 are alkylene, y1 is carboxyl, cyano, hydroxy, alkoxy, phenoxy, thienyl, pyridyl, aminocarbonyl, sulfonylamino, phenyl, acylamino, carboxylamino, amino, etc. and Y2 is phenyl) or its pharmaceutically acceptable salt, its preparation process and pharmaceutical compositions containing these compounds as effective ingredients. These compounds have strong antithrombotic activity, cardiotonic activity, vasodilator activity and anti-SRS-A activity, and are useful as prophylactic or therapeutic agents for various thrombotic affections, congestive heart failure, hypertension, asthma, immediate type allergy diseases and the like.

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