Tetrahydroquinoline derivatives as gamma secretase inhibitors

Details Tetrahydroquinoline derivatives as gamma secretase inhibitors Tetrahydroquinoline derivatives as gamma secretase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/475 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 215/58 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2455863

This invention discloses novel gamma secretase inhibitors of the formula: (see formula 1.0) wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, -X(CO)Y, -(CR3 2)l-4X(CO)Y; each R3A is independently H or alkyl; X is - O-, - NH, or -N-alkyl; and Y is -NR6R7, or -N(R3)(CH2)2-6NR6R7. Also disclosed is a method of treating Alzheimer's Disease.

L'invention concerne de nouveaux inhibiteurs de gamma-sécrétase représentés par la formule (I), dans laquelle R?1¿ représente un groupe aryle substitué ou hétéroaryle substitué, R?2¿ représente un groupe R?1¿, alkyle, -X(CO)Y, -(CR?3¿¿2?)¿1-4?X(CO)Y, chaque R?3A¿ représente indépendamment H ou alkyle, X représente -O-, -NH, ou -N-alkyle, et Y représente -NR?6¿R?7¿, ou -N(R?3¿)(CH¿2?)¿2-6?NR?6¿R?7¿. L'invention concerne également une méthode de traitement de la maladie d'Alzheimer.

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