Tfpi fragments as anti-microbial agents

Details Tfpi fragments as anti-microbial agents Tfpi fragments as anti-microbial agents

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/57 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2615777

Anti-microbial therapeutic agents that act via a novel method to treat infection are compounds which may comprise a peptide with natural or non- natural amino acids, or a small molecule. The agent can bind to the surface of a microorganism and productively fix complement in order to cause lysis of the microorganism via the assembly of a membrane attack complex, thereby triggering removal of the microbe by phagocytosis. The agents may be fragments of TFPI e.g. from the C-terminus region.

La présente invention concerne des agents thérapeutiques antimicrobiens agissant via une nouvelle méthode pour traiter l'infection qui sont des composés pouvant comprendre un peptide contenant des acides aminés naturels ou non naturels ou une petite molécule. L'agent peut se lier à la surface d'un micro-organisme et fixer de manière productive le complément afin de provoquer la lyse du micro-organisme via l'assemblage d'un complexe d'attaque membranaire, ce qui déclenche l'élimination du microbe par phagocytose. Les agents peuvent être des fragments de TFPI provenant, par exemple, de la région C-terminale.

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