Human antibodies that bind human tnf.alpha.

Details Human antibodies that bind human tnf.alpha. Human antibodies that bind human tnf.alpha.

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 47/30 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2596476

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor a (hTNF.alpha.) are disclosed. These antibodies have high affinity for hTNF.alpha. (e.g., K d= 10 -8 M or less), a slow off rate for hTNF.alpha. dissociation (e.g., K off =10 -3sec-1 or less) and neutralize hTNF.alpha. activity in vitro and in vivo. An antibody of the invention can be a full--length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNF.alpha. and for inhibiting hTNF.alpha. activity, e.g., in a human subject suffering from a disorder in which hTNF.alpha. activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

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