Sustained-release tablet comprising reboxetine

Details Sustained-release tablet comprising reboxetine Sustained-release tablet comprising reboxetine

A - Human Necessities

61

K

A61K 31/5375 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2492424

A sustained-release pharmaceutical composition in s form of an orally deliverable tablet comprises an active pharmaceutical agent having solubility not less than about 10 mg/ml, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm-2 at a solid fraction representative of the tablet.

L'invention concerne une composition pharmaceutique à libération prolongée se présentant sous la forme d'un comprimé administrable par voie orale. Cette composition comprend un agent pharmaceutique actif, possédant une solubilité supérieure ou égale à 10 mg/ml, dispersé dans une matrice comprenant un polymère hydrophile et un amidon possédant une résistance à la traction d'au moins 0,15 kN cm?-2¿, l'essai étant réalisé sur une fraction solide représentative du comprimé.

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