Synergistic filler composition of pvp-va and silicified...

Details Synergistic filler composition of pvp-va and silicified... Synergistic filler composition of pvp-va and silicified...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Type

Patent

Patent number

CA 2454449

Description

A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.

L'invention se rapporte à une composition de charge synergistique permettant de fabriquer des comprimés pharmaceutiques dont la dureté est suffisante en faisant intervenir une faible force de compression et une faible friabilité. Ainsi, le comprimé est plus résistant au traitement et il n'est pas nécessaire d'augmenter la taille dudit comprimé qui renferme (a) un copolymère PVP-VA et (b) une cellulose microcristalline.

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