A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/404 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2543942
Compounds and compositions including 6-bromo-indirubin, 5-amino-indirubin and N-methyl-indirubins and related indirubin derivatives are provided that are useful as selective modulators of glycogen synthase kinase-3, cyclin-dependent protein kinases or aryl hydrocarbon receptors. Methods of inhibiting or modulating cell growth or cell cycling are provided using the compounds of the invention. In other aspects, compounds and methods for the treatment of protozoan-mediated diseases, Alzheimer's disease and diabetes are provided.
L'invention porte: sur des composés et des compositions contenant de la 6-bromo-indirubine, de la 5-amino-indirubine et des N-méthyl-indirubines et les dérivés d'indirubine associés modulateurs sélectifs de la glycogène synthase kinase-3, et des récepteurs dépendant de la cycline de protéines kinases et/ou de l'arylhydrocarbone. L'invention porte également sur des méthodes d'inhibition ou modulation de la croissance cellulaire ou du cycle cellulaire utilisant lesdits composés et sur ces composés et méthodes de traitement de maladies médiées par le protozoan, de la maladie d'Alzheimer, et du diabète.
Greengard Paul
Knockaert Marie
Meijer Laurent
Skaltounis Alexios-Leandros
Centre National de La Recherche Scientifique
Kirby Eades Gale Baker
The Rockefeller University
LandOfFree
Indirubin-type compounds, compositions, and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indirubin-type compounds, compositions, and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indirubin-type compounds, compositions, and methods for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1454471