C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/32 (2006.01) A61K 39/07 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2045950
The invention provides a vaccine for the prevention and/or the treatment of infection by Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, which vaccine contains at least an immunogenic part of at least one cytolytic protein of A. pleuropneumoniae produced by recombinant DNA, and detoxified derivatives thereof. Three of such cytolytic proteins are identified and a vaccine containing these, or parts or derivatives thereof, ensures protection against all known serotypes of A. pleuropneumoniae. The cytolytic proteins are produced by inserting a nucleotide sequence encoding one or more of the proteins or parts thereof in a host cell, cultivating the host cell and recovering the proteins. Another vaccine contains the genetic information for one or more of the cytolytic proteins, and a passive vaccine contains antibodies against these proteins. The invention further provides monoclonal,antibodies and DNA probes for use in diagnostics.
Kamp Elbarte M.
Smits Marinus A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Centraal Diergeneeskundig Instituut
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