Isolation and mobilization of stem cells expressing vegfr-1

Details Isolation and mobilization of stem cells expressing vegfr-1 Isolation and mobilization of stem cells expressing vegfr-1

A - Human Necessities

61

K

A61K 39/395 (2006.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61P 9/10 (2006.01) C07K 14/71 (2006.01) C07K 14/705 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2454251

The present invention is directed to methods of isolating mammalian stem cells expressing the VEGF receptor VEGFR-1 and compositions thereof. The present invention is also directed to methods of using such isolated mammalian stem cells expressing VEGFR-1 to treat various conditions, which can involve inducing hematopoiesis, vasculogenesis and/or angiogenesis, myogenesis, and neurogenesis to treat the various condition. Finally, the present invention is directed to therapeutic methods using a molecule that binds and activates or stimulates VEGFR-1, for example, P1GF, to stimulate proliferation and/or differentiation and mobilization, i.e., motogenesis, of stem cells.

L'invention concerne des procédés d'isolation de cellules souches mammifères exprimant le récepteur VEGFR-1 et des compositions de celles-ci. L'invention concerne également des procédés d'utilisation de telles cellules souches mammifères exprimant VEGFR-1, aux fins de traitement de divers états, notamment l'hématopoïèse, la vasculogénèse et/ou l'angiogénèse, la myogénèse et la neurogénèse, aux fins de traitement de divers états. L'invention concerne enfin des méthodes thérapeutiques mettant en oeuvre une molécule liant et activant ou stimulant VEGFR-1, par exemple, P1GF, aux fins de stimulation de la prolifération et/ou différentiation et de la mobilisation, c'est-à-dire, la motogénèse, de cellules souches.

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