N4-acylcytosine nucleosides for treatment of viral infections

Details N4-acylcytosine nucleosides for treatment of viral infections N4-acylcytosine nucleosides for treatment of viral infections

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/7068 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2470255

The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animals hosts, comprising the administration of N4-acyl-2',3'-dideoxy-5- flluorocytidine or N4-acyl-2',3'-didehydro-2',3' dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.

L'invention concerne un procédé et une composition de traitement ou de prévention d'infections virales, notamment des infections par le virus de l'immunodéficience humaine (VIH) et par le virus de l'hépatite B (VHB), chez des patients humains ou d'autres hôtes animaux. Ledit procédé consiste à administrer de la N?4¿-acyl-2',3'-didésoxy-5-fluorocytidine ou de la N?4¿-acyl-2',3'-didéhydro-2',3' didésoxy-5-fluorocytidine, ainsi que des sels acceptables au plan pharmaceutique, des promédicaments et d'autres dérivés.

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