Treatment and prevention of vascular disease

Details Treatment and prevention of vascular disease Treatment and prevention of vascular disease

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/495 (2006.01) C07K 14/81 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2324476

The present invention relates to the discovery that a nucleic acid molecule as set forth in SEQ ID NO:1 encodes a polypeptide (SEQ ID NO:2) that mediates the intracellular signal induced by the binding of TGF.beta. to specific cell surface receptors. In addition, it has been determined that the polypeptide of SEQ ID NO:2 also acts to increase the secretion of TGF.beta.. Moreover, the polypeptide (SEQ ID NO:4) encoded by the nucleic acid molecule as set forth in SEQ ID NO:3 was determined to modulate the activity of SEQ ID NO:2.

La présente invention se rapporte à une molécule d'acide nucléique représentée par SEQ ID NO:1 et codant un polypeptide (SEQ ID NO:2) qui assure la médiation du signal intracellulaire induit par la liaison du TGF.beta. vers des récepteurs spécifiques de surfaces cellulaires. On a en outre établi que le polypeptide de SEQ ID NO:2 agit également de façon à accroître la sécrétion de TGF.beta.. De plus, on a établi que le polypeptide (SEQ NO:4) codé par la molécule d'acide nucléique représentée par SEQ NO:3 module l'activité de SEQ NO:2.

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