Disodium 4-chlorophenylthiomethylenebisphosphonate...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/38 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2103655

IN THE CANADIAN PATENT AND TRADEMARK OFFICE PATENT APPLICATION entitled: Disodium 4-chlorophenylthiomethylenebisphos- phonate monohydrate, its preparation and pharmaceutical compositions in which it is present in the names of: Michel BONNERY Michel BOUISSET Rapha?l SOLE Assignee: ELF SANOFI ABSTRACT OF THE DISCLOSURE The present invention relates to disodium 4- chlorophenylthiomethylenebisphosphonate monohydrate. The invention further relates to the method of preparing this monohydrate. The invention further relates to the pharma- ceutical compositions in which disodium tiludronate monohydrate is present as the active principle.

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