A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2455884
The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of collagen VI; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation.
L'invention concerne, entre autres, des compositions et des procédés permettant de traiter, prévenir et diagnostiquer des maladies ou des états associés à un taux anormal ou une activité anormale du biglycane, des maladies ou des états associés à un taux anormal ou une activité anormale du collagène VI, des troubles associés à une membrane cytoplasmique instable, à cause, par ex. d'un complexe protéique associé à la dystrophine (DAPC) instable, et des troubles associés à des synapses anormales ou à des jonctions neuromusculaires anormales, notamment celles résultant d'une activation anormale de MuSK ou d'une agrégation anormale du récepteur d'acétylcholine (AChR).
Amenta Alison
Bowe Mark
Fallon Justin R.
Hagiwara Hiroki
Mckechnie Beth
Borden Ladner Gervais Llp
Brown University
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