Use of caspase-14 and caspase-14 modulators to diagnose...

Details Use of caspase-14 and caspase-14 modulators to diagnose... Use of caspase-14 and caspase-14 modulators to diagnose...

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 31/203 (2006.01) A61K 31/573 (2006.01) A61K 31/593 (2006.01) A61K 31/7088 (2006.01) A61K 33/06 (2006.01) A61K 33/14 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2390510

The present invention is based on the finding that caspase-14 is expressed in epithelial tissue such as the epidermis, the epithelial layer of the choroid plexus and the pigmented retinal layer. The invention relates to the involvement of caspase-14 in keratinocyte differentiation and in a properly functioning blood-brain barrier and blood-eye barrier. The present invention specifically relates to nucleic acids encoding caspase-14, caspase-14 protein and modulators of caspase-14 expression, activation and bioactivity that can be used to diagnose and/or treat keratinocyte differentiation disorders, disturbances in the blood-eye barrier and brain disorders.

La présente invention se base sur la découverte que la caspase-14 est exprimée dans les tissus épithéliaux, tel que l'épiderme, la couche épithéliale du plexus choroïde et la couche rétinienne pigmentée. L'invention concerne l'implication de la caspase-14 dans la différenciation des kératinocytes, ainsi que dans une barrière hémato-encéphalique et une barrière oeil-sang fonctionnant correctement. L'invention concerne plus particulièrement des acides nucléiques codant la caspase-14, la protéine de caspase-14 et les modulateurs d'expression de la caspase-14, ainsi que l'activation et la bioactivité pouvant être utilisée pour diagnostiquer et/ou traiter des troubles de la différenciation des kératinocytes, des anomalies de la barrière oeil-sang et des maladies neurodégénératives.

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