Novel benzothiazepine and benzothiepine compounds

Details Novel benzothiazepine and benzothiepine compounds Novel benzothiazepine and benzothiepine compounds

C - Chemistry, Metallurgy

07

D

C07D 281/10 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/395 (2006.01) A61K 31/4025 (2006.01) A61K 31/428 (2006.01) A61K 31/439 (2006.01) A61K 31/4995 (2006.01) A61K 31/5375 (2006.01) A61K 31/541 (2006.01) A61K 31/554 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07D 337/08 (2006.01) C07D 409/12 (2006.01) C07D 453/02 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2557576

A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substituent: (see formula 1A)

L'intention est de fournir un médicament utile comme remède et comme agent préventif pour l'hyperlipémie ; un médicament également utile comme remède et comme agent préventif pour des troubles du foie accompagnant une stase de la bile, en particulier une cirrhose primitive biliaire, une cholangite primitive sclérosante et ainsi de suite ; et un médicament utile comme remède et comme agent préventif pour l'obésité, la stéatose hépatique et la stéato-hépatite. Composé de benzothiazépine ou de benzothiépine représenté par la formule générale (1A) suivante lequel a une liaison thioamide et un substituant ammonium quaternaire : A ortho B méta C para (1A)

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