16-ene-vitamin d derivatives

Details 16-ene-vitamin d derivatives 16-ene-vitamin d derivatives

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07J 7/00 (2006.01) C07J 9/00 (2006.01) C07J 31/00 (2006.01)

Patent

CA 2275382

Vitamin D derivatives of general formula (1) wherein X represents oxygen or sulfur; R11 represents saturated or unsaturated aliphatic hydrocarbyl which may be substituted by hydroxyl or protected hydroxyl, or -COR12 (wherein R12 represents alkyl, aryl or alkoxyl); R2 represents -OR9 or hydrogen; and R9 and R10 each represent hydrogen or hydroxyl; a process for producing them; intermediates for them; and medicines characterized by containing them.

Dérivés de vitamine D de la formule générale (1). Dans ladite formule, X représente oxygène ou soufre; R¿11? représente hydrocarbyle aliphatique saturé ou insaturé pouvant être substitué par hydroxyle ou hydroxyle protégé, ou bien -COR¿12? (où R¿12? est alkyle, aryle, ou alcoxyle); R¿2? représente -OR¿9? ou hydrogène; et R¿9? et R¿10? représentent chacun hydrogène ou hydroxyle. On décrit aussi un procédé de fabrication, des produits intermédiaires et des médicaments caractérisés en ce qu'ils renferment ces dérivés.

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