Antibiotic carbapenem derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 477/00 (2006.01) A61K 31/40 (2006.01) C07C 229/56 (2006.01) C07C 229/62 (2006.01) C07C 229/64 (2006.01) C07C 233/54 (2006.01) C07C 237/30 (2006.01) C07C 255/58 (2006.01) C07C 309/58 (2006.01) C07C 323/63 (2006.01) C07D 207/16 (2006.01) C07D 403/12 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01) C07F 9/547 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2107781

2107781 9217481 PCTABS00016 A carbapenem compound of formula (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 is hydroxy or carboxy; and the phenyl ring is optionally further substituted by one or two substituents selected from halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, trifluoromethyl, C1-4alkoxycarbonyl, carbamoyl, C1-4alkylcarbamoyl, di-C1-4alkylcarbamoyl, amino, C1-4alkylamino, di-C1-4alkylamino, sulphonic acid, C1-4alkylS(O)n- (wherein n is 0-2), N-C1-4alkanesulphonamido, C1-4alkanoylamino and C1-4alkanoyl(N-C1-4alkyl)amino; provided that the phenyl ring is substituted by at least one carboxy; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof.

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