Pharmaceutical composition comprising a...

Details Pharmaceutical composition comprising a... Pharmaceutical composition comprising a...

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) A61K 31/58 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2756926

The invention provides a pharmaceutical product comprising, in combination, (1 ) (1 R,3aS,3bS,1 OaR, 10bS, 11 S,12aS)1-{[(cyanomethyl)sulfanyl]carbonyl}-7-(4-fluorophenyl)-11-hydroxy- 10a,12a-dimethyl-1,2,3,3a,3b, 4,5,7,10,10a, 10b, 1 1,12,12a- tetradecahydrocyclopenta[1,2-f]indazol-1 -yl furan-2-carboxylat and (2) a'beta'2 adrenoreceptor agonist, a dual 'beta'2 adrenoreceptor agonist/M3 receptor antagonist or a muscarinic antagonist, and the use of said product in treating respiratory dis-eases.

L'invention concerne un produit pharmaceutique comprenant, en combinaison, (1 ) du (1R,3aS,3bS,1 OaR,10bS,11S,12aS)1-{[(cyanométhyl)sulfanyl]carbonyl}-7-(4-fluorophényl)-11-hydroxy-10a,12a-diméthyl-1,2,3,3a,3b, 4,5,7,10,10a,10b,11,12,12a-tétradécahydrocyclopenta[1,2-f]indazol-1-yl furan-2-carboxylate et (2) un agoniste de l'adrénorécepteur 'bêta'2, un composé à activité double : agoniste de l'adrénorécepteur 'bêta'2/antagoniste du récepteur M3 et antagoniste muscarinique, et l'utilisation dudit produit dans le traitement des maladies respiratoires.

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