A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) A61K 45/06 (2006.01) A61P 9/08 (2006.01) A61P 15/10 (2006.01)
Patent
CA 2431077
The invention relates to a pharmaceutical preparation containing at least one compound of formula (I), wherein R1~, R2~, R3~, R4~ and X have the meanings as cited in Claim No. 1, and to their physiologically safe salts and/or solvates, and containing; a) at least one antithrombotic agent or; b) at least one calcium antagonist or; c) at least on prostaglandin or prostaglandin derivative for producing a medicament used for treating angina, hypertension, pulmonary hypertension, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), cor pulmonale, right ventricular failure, atherosclerosis, conditions of reduced patency of the heart vessels, peripheral vascular diseases, cerebrovascular accident, bronchitis, allergic asthma, chronic asthma, allergic rhinitis, glaucoma, irritable bowel syndrome, tumors, kidney failure, cirrhosis of the liver, and for treating female sexual dysfunctions.
L'invention concerne une préparation pharmaceutique contenant au moins un composé de formule (I) dans laquelle R<1>, R<2>, R<3>, R<4> et X ont les significations mentionnées dans la description, ainsi que leurs sels et/ou solvates physiologiquement tolérables et a) au moins un antithrombotique ou b) au moins un antagoniste de calcium ou c) au moins une prostaglandine ou un dérivé de prostaglandine. Cette préparation s'utilise pour produire un médicament employé pour traiter l'angine, l'hypertension artérielle, l'hypertension pulmonaire, l'insuffisance cardiaque globale (ICG), la broncho-pneumopathie chronique obstructive (BPCO), le coeur pulmonaire, l'insuffisance du ventricule droit, l'athérosclérose, les états de perméabilité réduite des vaisseaux cardiaques, les maladies vasculaires périphériques, l'ictus, la bronchite, l'asthme allergique, l'asthme chronique, la rhinite allergique, le glaucome, le côlon irritable, des tumeurs, l'insuffisance rénale, la cirrhose du foie, ainsi que les troubles sexuels chez la femme.
Eggenweiler Hans-Michael
Eiermann Volker
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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