Composition for enhancing lipid production, barrier...

A - Human Necessities – 61 – K

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Details

A61K 8/44 (2006.01) A61K 8/36 (2006.01) A61K 8/365 (2006.01) A61K 8/67 (2006.01) A61Q 17/00 (2006.01) A61Q 17/04 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2338252

Increased production of skin lipids, increased barrier function, hydrogen peroxide neutralization, prevention of loss of the natural moisturizing factor from the stratum corneum and moisturization of the skin is provided by a topically applicable composition which includes one or more components selected from the group consisting of branched chain amino acids, derivatives of branched chain amino acids and mixtures thereof, which one or more components are capable of being catabolized in epidermal cells to form lipid precursors for epidermal lipid synthesis. The composition can also include one or more enzyme activators which increase the rate of catabolism of the one or more components.

La présente invention concerne une composition à application locale qui favorise la production des lipides cutanés, la fonction de barrière, la neutralisation du peroxyde d'hydrogène, l'hydratation de la peau et qui prévient la perte du facteur d'hydratation naturelle au niveau de la couche cornée de l'épiderme. Cette composition renferme un ou plusieurs composants pris dans le groupe de composés d'acides aminés à chaîne ramifiée, de dérivés d'acides aminés à chaîne ramifiée et de mélanges des uns et des autres. Un ou plusieurs de ces composants est susceptible d'être catabolysé dans les cellules de l'épiderme et de former des précurseurs lipides pour la synthèse de lipides cutanés. Cette composition peut également inclure un ou plusieurs activateurs enzymatiques qui augmentent le taux de catabolisme de l'un ou de plusieurs des composants.

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