Oligonucleotides and their use in an assay for encephalopathies

Details Oligonucleotides and their use in an assay for encephalopathies Oligonucleotides and their use in an assay for encephalopathies

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2115829

2115829 9304198 PCTABS00020 Oligonucleotides of formula: (X)a-(6N-palindrome)n-(Y)b, wherein "6N-palindrome" represents TACGTA, ACGTAT, CGTATA, GTATAC, TATACG or ATACGT (read in the conventional notation with the 5'-end at the left); n is an appropriate integer of at least 2; X is a length of appropriate 5'-end or tailing DNA and a is 0 or 1; and Y is a length of appropriate 3'-end or heading DNA and b is 0 or 1; or any labelled form thereof or any derivative thereof which retains the ability of the 6N-palindrome sequence to anneal or hybridise to its complementary sequence are useful in assay of encephalopathies such as scrapie, BSE or CJD. Preferably they are used as PCR primers to amplify DNA in the sample. PCR product can be detected by restriction with an appropriate enzyme and comparing the restricted and unrestricted products.

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