A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/785 (2006.01) A61K 31/132 (2006.01) A61P 3/12 (2006.01)
Patent
CA 2622021
The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administering to the patient an amount of a dendrimer composition effective to prevent absorption of substantial amounts of phosphate from the patient's GI tract. In a preferred version, a dose of between 2.5 and 15 grams per day is effective to prevent over 80% of phosphate present in the patient's GI tract from being absorbed. The dendrimer composition may comprise a hydrochloride, hydrobromide, hydroacetate or hydroanionic form.
La présente invention concerne des procédés et des compositions améliorés destinés au contrôle thérapeutique et/ou à la réduction des niveaux de phosphate sérique chez des animaux et patients mammifères. Les procédés comprennent l~administration au patient d~une quantité d~une composition de dendrimère efficace pour empêcher l~absorption de quantités substantielles de phosphate à partir du tractus gastro-intestinal du patient. Dans une version préférée, une dose quotidienne comprise entre 2,5 et 15 grammes est efficace pour empêcher une absorption supérieure à 80 % du phosphate présent dans le tractus gastro-intestinal du patient. La composition de dendrimère peut comprendre un chlorhydrate, un bromhydrate, un hydroacétate ou un hydroacétate ou une forme hydroanionique.
Barcyka Katarzyna
Deluca Hector F.
Williams Katie Beth
Goudreau Gage Dubuc
Wisconsin Alumni Research Foundation
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