Anti-idiotypic antibodies that mimic tnf

Details Anti-idiotypic antibodies that mimic tnf Anti-idiotypic antibodies that mimic tnf

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2074662

Abstract of the Disclosure Anti-idiotypic antibodies that mimic tumor necrosis factor (TNF) activity. The antibodies may be raised in one species (e.g. a rabbit) using a monoclonal anti-TNF antibody from another species (e.g. a mouse) as an immunogen. Such anti- idiotypic antibodies were cytotoxic to TNF-sensitive cell lines. The cytotoxic activity of the anti-idiotypic antibodies can be neutralized by antibodies that bind to TNF. The anti-idiotypic antibodies may be useful themselves as TNF antagonists or as TNF agonists, and may also be the basis for a new group of TNF agonists or antagonists.

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