Phenylalaninol derivatives

Details Phenylalaninol derivatives Phenylalaninol derivatives

C - Chemistry, Metallurgy

07

C

C07C 233/80 (2006.01) C07C 231/12 (2006.01) C07C 315/04 (2006.01) C07C 317/44 (2006.01) C07C 319/20 (2006.01) C07C 323/60 (2006.01)

Patent

CA 2362833

Compounds of formula (1) and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined in the specification, are effective inhibitors of the binding of VCAM-1 to VLA-4 in vivo and are useful in treating inflammation in inflammatory diseases in which such binding acts to bring on the inflammation.

Cette invention a trait à des composés correspondant à la formule (1) ainsi qu'à leurs sels et à leurs esters acceptables du point de vue pharmaceutique. Dans cette formule, X et Y sont tels que définis dans le descriptif. Ces substances, qui se révèlent d'efficaces inhibiteurs de la fixation de VCAM-1 à VLA-4 in vivo, sont des plus utiles dans le traitement de maladies inflammatoires dans lesquelles ce type de fixation déclenche l'inflammation.

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