C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61P 33/06 (2006.01) C07K 14/445 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2714121
The present invention relates to an aptamer or an active fragment thereof raised against the semi-conserved duffy binding ligand domain la, DBL1.alpha., region of the Plasmodium falciparum erythrocyte membrane protein 1, PfEMPI, which aptamer has an effect against malaria, in particular severe cerebral malaria.
La présente invention porte sur un aptamère ou un fragment actif de celui-ci dirigé contre la région semi-conservée du domaine du ligand de liaison Duffy 1a, DBL1a, de la protéine membranaire 1 des érythrocytes de Plasmodium falciparum, PfEMPI, lequel aptamère a un effet à l'encontre de la malaria, en particulier l'accès pernicieux à forme cérébrale sévère.
Lindh Johan
Persson Tina
Borden Ladner Gervais Llp
Forskarpatent I. Syd Ab
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