Stable therapeutic radionuclide compositions and methods for...

Details Stable therapeutic radionuclide compositions and methods for... Stable therapeutic radionuclide compositions and methods for...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2066779

Stable therapeutic radionuclide compositions comprising, for example, 186Re, 188Re and 131f stably bound to a proteina- ceous targeting moiety and suitable for human in vivo administration are disclosed. Stabilizing agents preferably comprise an tioxidants and challenging agents, and combination of HSA with an antioxidant and/or challenging agent provides enhanced long term stability. Ascorbic acid is an especially preferred stabilizing agent, which provides stability of therapeutic radionuclide compositions at levels of at least about 90 % for several hours up to several days.

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