C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 3/10 (2006.01) C07K 14/47 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2698393
The present invention relates generally to the fields diabetes. More particularly, it concerns the identification of genes responsible for NIDDM for use in diagnostics and therapeutics. The present invention demonstrates that the MODY3 locus is, in fact, the HNF-1.alpha. gene, MODY4 locus is the HN-F1.beta. and the MODY1 locus is the HNF-4.alpha. gene. The invention further relates to the discovery that analysis of mutations in the HNF- 1.alpha., HNF-1.beta. and HNF-4.alpha. genes can be diagnostic for diabetes. The invention also contemplates methods of treating diabetes in view of the fact that HNF-1.alpha., HNF-1.beta. and HNF-4.alpha. mutations can cause diabetes.
Bell Graeme
Furuta Hiroto
Horikawa Yukio
Kaisaki Pamela J.
Menzel Stephan
Arch Development Corporation
Deeth Williams Wall Llp
LandOfFree
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