Novel amino carboxy alkyl derivatives of barbituric acid

Details Novel amino carboxy alkyl derivatives of barbituric acid Novel amino carboxy alkyl derivatives of barbituric acid

C - Chemistry, Metallurgy

07

D

C07D 239/62 (2006.01) A61K 31/515 (2006.01) A61K 31/675 (2006.01) A61P 25/28 (2006.01) C07D 239/66 (2006.01) C07D 403/04 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2406396

The present invention relates to therapeutically active novel amino, carboxy, alkyl derivatives of barbituric acid of Formula (I), wherein at least one of R1, R2, R3 or R4 comprises an NH2 moiety and at least one of R1, R2, R3 or R4 comprises one COOH moiety. Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.

Cette invention concerne de nouveaux dérivés amino, carboxy, alkyle d'acide barbiturique thérapeutiquement actifs, représentés par la formule (I), dans laquelle au moins un élément parmi R1, R2, R3 ou R4 comprend un groupe caractéristique NH¿2? et au moins un élément parmi R1, R2, R3 ou R4 comprend un groupe caractéristique COOH. Cette invention concerne également un procédé de préparation des composés de formule (I), ainsi que des compositions pharmaceutiques comprenant ces composés. Ces nouveaux composés agissent comme des modulateurs des récepteurs du glutamate métabotropique et, en tant que tels, sont utiles dans le traitement de maladies du système nerveux central liées au système des récepteurs du glutamate métabotropique.

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