Use of lipoxin compounds for inhibiting of tnf-(alpha)...

Details Use of lipoxin compounds for inhibiting of tnf-(alpha)... Use of lipoxin compounds for inhibiting of tnf-(alpha)...

A - Human Necessities

61

K

A61K 31/557 (2006.01) A61K 31/202 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2747376

The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNF.alpha.)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1 to 10 nM, the LXA4 and ATL analogs each inhibited TNF.alpha.-stimulated superoxide anion generation and IL-1.beta. release by human PMN.

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