Inhibition of arthritis by l-type calcium channel antagonists

Details Inhibition of arthritis by l-type calcium channel antagonists Inhibition of arthritis by l-type calcium channel antagonists

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/275 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2182114

The present invention comprises new methods for treating rheumatoid arthritis. It has been found that the L- type calcium channel antagonists are ef- fective in treating arthritis. Dihydropy- ridines, phenylalkylamines, and benzyl- diazepines are examples of the classes of L-type calcium channel antagonists en- compassed by the invention. Nimodip- ine, nisoldipine, nifedipine, verapamil and diltiazem are examples of specific compounds useful in the present inven- tion.

Nouvelles méthodes de traitemnt de l'arthrite rhumatoïde. On a trouvé que les antagonistes des vannes à calcium de type L sont efficaces pour traiter l'arthrite. Les dihydropyridines, les phénylalkylamines et les benzyldiazépines sont des exemples des classes d'antagonistes des vannes à calcium de type L entrant dans le cadre de la présente invention. La nimodipine, la nisoldipine, la nifédipine, le vérapamil et le diltiazem sont des composés spécifiques utiles dans la présente invention.

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