Use of cardiotrophin in hepatic diseases

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 38/19 (2006.01) A61P 1/16 (2006.01)

Patent

CA 2461007

The invention relates to the use of cardiotrophin in hepatic diseases. The invention describes the increased expression of cardiotrophine (CT-1) during the hepatic regeneration process which coincides with the maximum proliferation of hepatocytes. Said invention also relates to the role of CT-1 as a hepatic regeneration stimulator. Moreover, said invention details the hepatoprotective role of CT-1 in different acute hepatic injury models. All of the above reveals the importance of the use of CT-1 in the production of compositions used in the treatment of hepatopathies. The invention relates to said use of CT-1 in different forms and methods, including the recombinant protein and the use of gene sequences that code for CT-1.

L'invention concerne l'utilisation de la cardiotrophine dans les maladies hépatiques. L'invention concerne également l'augmentation de l'expression de la cardiotrophine (CT-1) au cours du processus de régénération hépatique coïncidant avec une prolifération maximale d'hépatocytes, ainsi que le rôle de la CT-1 comme stimulateur de la régénération hépatique. L'invention concerne également le rôle hépatoprotecteur de la CT-1 dans différents modèles de douleur hépatique aigüe. Tout ceci met en relief l'importance de l'utilisation de la CT-1 dans la fabrication de compositions utilisées dans le traitement des hépatopathies. L'invention concerne cette utilisation sous différentes formes et procédés, y compris la protéine de recombinaison et l'utilisation des séquences géniques codant pour la CT-1.

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